Do you develop a dependency to Clindoxyl Gel? In short, no. (See bottom of entry for dependency info)
I seem to be getting a lot of traffic for the search term "clindoxyl gel dependency," so I thought I'd make a more-to-the-point post than my previous blog entries about it. Clindoxyl is a gel that usually comes in a tube and does not require refrigeration. It is a mixture of benzoyl peroxide and an antibiotic. It takes up to 6 weeks (6 full weeks!!) To see optimal results and, between weeks 0 and 6 of its use, it might seem like it's making things worse.
In my experience, Clindoxyl gel worked wonderfully. At about 4 weeks of use, my face must have been 1.5 times worse than before I started using it, but after 6 weeks of use, my skin was amazingly clear and I went on to use benzoyl peroxide for a year or two with perfect skin until it stopped working.
Do you develop a dependency to Clindoxyl Gel? In short, no. You are prescribed this gel when you have moderate acne... This acne is not generally something that can be "cured" through topical ointments or gels. However, it is something that can be maintained or controlled through topical medications. Clindoxyl works by fighting bacteria that lives deep in your skin while the benzoyl peroxide acts as an antiseptic deep in your pores to help the antibiotics reach further down and to help bring oxygen to where it's needed. Once you stop using clindoxyl, you will break out... This isn't due to a dependency of the gel, it is due to your pre-exiting acne condition which you had previously been controlling with the prescription cream.
If you are well controlled with your clindoxyl, you can try using pure benzoyl peroxide as it might be better for you financially. I used clindoxyl for about 3 months prior to switching to straight benzoyl. I purchased mine from acne.org.